ABSTRACT
Liposomal amphotericin B L-Amp B, a novel formulation of Amp B, is effective for the
treatment of invasive fungal infections in children and adults and is associated with
less toxicity than the conventional preparation. Data on the use of L-Amp B in neonates
is scarce. We describe the clinical course of two premature infants who were treated
with L-Amp B (one infant had candidemia, and the other had candidemia and meningitis),
and provide a summary of previously published experience on this topic. L-Amp B may
be an option for therapy of invasive candidiasis in neonates who are at high risk
of nephrotoxicity and other amphotericin-related reactions, but clinical trials are
necessary to document its safety and efficacy in this age group.
Keywords
Liposomalamphotericin - neonate - candidiasis - meningitis
